Below please find all papers generated by the Lead Identification Division and its scientific staff. If an article is available for viewing in PubMed, clicking on the PubMed ID (PMID) number for the relevant article will direct you to the appropriate viewing website.
There are currently 159 papers that have been either published or accepted.
159 – Smith E, Dickson L, Pickford P, Rowland A, Shumate J, Perez K, Scampavia L, Hernandez D, Spicer T. 158 – Aziz F, Reddy K, Fernandez-Vega V, Dey R, Hicks K, Rao S, Ortiz L, Smith E, Shumate J, Scampavia L, Carpino N, Spicer T, French J. 157 – Ortiz L, Fernandez-Vega V, Shumate J, Peles A, Zeiger J, Scampavia L, Spicer T. 156 – Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi Y, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun Y, Rizzo RC, Haley JD. 155 – Lee E, Archasappawat S, Ji K, Pena J, Fernandez-Vega V, Gangaraju R, Beesabathuni NS, Kim MJ, Tian Q, Shah P, Scampavia L, Spicer T, Hwang CI 154 – Rajan RG, Fernandez-Vega V, Sperry J, Nakashima J, Do LH, Andrews W, Boca S, Islam R, Chowdhary SA, Seldin J, Souza GR, Scampavia L, Hanafy KA, Vrionis FD, Spicer TP 153 – Hou S, Li Z, Chen X, Wang W, Duan T, Scampavia L, Yuan Y, Spicer TP, Chen X, Xie T 152 – Liao GY, Xu H, Shumate J, Scampavia L, Spicer T, Xu B 151 – Fernandez-Vega V, Yang D, Jordán LO, Ye F, Conway L, Chen LY, Shumate J, Baillargeon P, Scampavia L, Souza G, Parker C, Shen B, Spicer TP 150 – Liu Z, Chen K, Dai J, Xu P, Sun W, Liu W, Zhao Z, Bennett SP, Li P, Ma T, Lin Y, Kawakami A, Yu J, Wang F, Wang C, Li M, Chase P, Hodder P, Spicer TP, Scampavia L, Cao C, Pan L, Dong J, Chen Y, Yu B, Guo M, Fang P, Fisher DE, Wang J 149 – Smith E, Davis-Gardner ME, Garcia-Ordonez RD, Nguyen TT, Hull M, Chen E, Yu X, Bannister TD, Baillargeon P, Scampavia L, Griffin P, Farzan M, Spicer TP 148 – Reed A, Ichu TA, Milosevich N, Melillo B, Schafroth MA, Otsuka Y, Scampavia L, Spicer TP, Cravatt BF 147 – Moghadasi SA, Esler MA, Otsuka Y, Becker JT, Moraes SN, Anderson CB, Chamakuri S, Belica C, Wick C, Harki DA, Young DW, Scampavia L, Spicer TP, Shi K, Aihara H, Brown WL, Harris RS 146 – Souza G, Spicer TP 145 – Smith E, Campbell S, Wilson A, Shumate J, Baillargeon P, Scampavia L, Kamenecka T, Spicer TP, Solt L 144 – Fernandez-Vega V, Hou S, Plenker D, Tiriac H, Baillargeon P, Shumate J, Scampavia L, Seldin J, Souza G, Tuveson D, Spicer TP 143 – Rajendra Rao S, Kostic A, Baillargeon P, Fernandez-Vega V, Rios de Anda M, Fletcher K, Shumate J, Scampavia L, Buxbaum J, Spicer TP 142 – Baillargeon P, Fernandez-Vega V, Ortiz L, Shumate J, Marques N, Deng L, Spicer TP, Scampavia L 141 – Chulkov E, Smith E, Rohr C, Yahya N, Park S, Scampavia L, Spicer TP, Marchant J 140 – Mediouni S, Mou H, Otsuka Y, Jablonski J, Adcock R, Batra L, Chung D, Rood C, S. de Vera I, Rahaim Jr. R, Ullah S, Yu X, Getmanenko Y, Kennedy N, Wang C, Nguyen T, Hull M, Chen E, Bannister T, Baillargeon P, Scampavia L, Farzan M, Valente S, Spicer TP 139 – Shirey R, Hart J, Sridharan B, Novick S, Turner L, Zhou B, Nielsen A, Eubanks L, Ueno L, Hixon M, Lairson L, Spicer TP, Scampavia L, Griffin P, Vogt P, Janda K 138 – Stoveken H, Fernandez-Vega V, Muntean B, Patil D, Shumate J, Bannister J, Scampavia L, Spicer TP, Martemyanov 137 – Diez J, Rajendrarao S, Baajour S, Sripadhan P, Spicer TP, Scampavia L, Minond D 136 – Wang C, Diez J, Park H, Spicer TP, Scampavia L, Becker-Pauly C, Fields G, Minond D, Bannister T 135 – Hou S, Diez J, Wang C, Becker-Pauly C, Fields G, Bannister T, Spicer TP, Scampavia L, Minond D 134 – Spicer TP 133 – Smith E, Davis-Gardner M, Garcia-Ordonez R, Nguyen T, Hull M, Chen E, Baillargeon P, Scampavia L, Strutzenberg T, Griffin P, Farzan M, Spicer TP 132 – Smith E, Dukovski D, Shumate J, Scampavia L, Miller J, Spicer TP 131 – Llamosas N, Arora V, Vij R, Kilinc M, Bijoch L, Rojas C, Reich A, Sridharan B, Willems E, Piper D, Scampavia L, Spicer T, Miller C, Holder J, Rumbaugh G 130 – Grandjean J, Madhavan A, Cech L, Seguinot B, Paxman R, Smith E, Scampavia L, Powers E, Cooley C, Plate L, Spicer T, Kelly J, Wiseman R 129 – Otsuka Y, Airola M, Choi Y, Coant N, Snider J, Cariello C, Saied E, Arenz C, Bannister T, Rahaim R, Hannun Y, Shumate J, Scampavia L, Haley J, Spicer T 128 – Smith E, Janovick JA, Bannister T, Shumate J, Ganapathy V, Scampavia L, Spicer T 127 – Boca S, Bhuvaneshwar K, Fernandez-Vega V, Kancherla J, Rao S, Madhavan S, Riggins R, Beckman R, Bravo H, Scampavia L, Spicer T 126 – Wang L, Cheng C, Qin J, Xu M, Kao C, Shi J, You E, Gong W, Pedro-Rosa L, Chase P, Scampavia L, Madoux F, Spicer T, Hodder P, Xu H, Tsai S, Tsai M 125 – Pan C, Otsuka Y, Sridharan B, Woo M, Leiton C, Babu S, Goncalves M, Kawalerski R, Bai J, Change D, Biankin A, Scampavia L, Spicer T, Escobar-Hoyos L, Shroyer K 124 – Pan C, Leiton C, Roa-Pena L, Kawalerski R, Moffitt R, Zhao J, Spicer T, Bailey P, Chang D, Biankin A, Duong T, Singh P, Shroyer K, Escobar-Hoyos L 123 – Perez O, Pena J, Fernandez-Vega V, Scampavia L, Spicer T 122 – Baillargeon P, Spicer TP, Scampavia L Applications for Open Source Microplate-Compatible Illumination Panels 120 – Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera F, Willems E, Piper D, Scampavia L, Rumbaugh G, Spicer TP 119 – Morgan G, Yan N, Mortenson D, Rennella E, Blundon J, Gwin R, Lin C, Stanfield R, Brown S, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay L, Wilson I, Kelly J 118 – Zhou W, Yin Y, Smith E, Chou J, Shumate J, Scampavia L, Spicer TP, Carpino N, French JB 117 – Baillargeon P, Coss-Flores K, Singhera F, Shumate J, Williams H, DeLuca L, Spicer TP, Scampavia L 116 – Baillargeon P, Fernandez-Vega V, Sridharan B, Brown S, Griffin P, Rosen H, Cravatt B, Scampavia L, Spicer TP 115 – Spicer TP, Fernandez-Vega V, Scampvia L, Willetts L, Vessels M 114 – Spicer TP, Gardiner DL, Schoenen FJ, Roy S, Griffin PR, Chase P, Scampavia L, Hodder P, Trenholme KR 113 – Janovick JA, Spicer TP, Bannister TD, Smith E, Ganapathy V, Scampavia L 112 – Nieto A, Fernandez-Vega V, Spicer TP, Sturchler E, Adhikari P, Kennedy N, Mandat S, Chase P, Scampavia L, Bannister T, Hodder P, McDonald PH 111 – Quereda V, Hou S, Madoux F, Scampavia L, Spicer T, Duckett D 110 – Kota S, Hou S, Guerrant W, Madoux F, Troutman S, Fernandez-Vega V, Alekseeva N, Madala N, Scampavia L, Kissil J, Spicer T 109 – Muntean BS, Patil DN, Madoux F, Fossetta J, Scampavia L, Spicer T, Martemyanov KA 108 – Hou S, Tiriac H, Sridharan B, Scampavia L, Madoux F, Seldin J, Souza G, Watson D, Tuveson D, Spicer T 107 – Shumate J, Baillargeon P, Spicer T, Scampavia L 106 – Wolff R, Wang-Gillam A, Alvarez H, Tiriac H, Engle D, Hou S, Groff A, San Lucas A, Bernard V, Allenson K, Castillo J, Kim D, Mulu F, Huang J, Stephens B, Wistuba I, Katz M, Varadhachary G, Park Y, Hicks J, Chinnaiyan A, Scampavia L, Spicer T, Gerhardinger C, Maitra A, Tuveson D, Rinn J, Lizee G, Yee C, Levine A 105 – Smith E, Giuliano KA, Shumate J, Baillargeon P, McEwan B, Cullen MD, Miller JP, Drew L, Scampavia L, Spicer TP 104 – Spicer T, Hubbs C, Vaissiere T, Collia D, Rojas C, Kilinc M, Vick K, Madoux F, Baillargeon P, Shumate J, Martemyanov K.A., Page D.T., Puthanveettil S, Hodder P, Davis R, Miller C.A., Scampavia L, Rumbaugh G 103 – Singhera F, Cooper E, Scampavia L, Spicer T 102 – Kong J, Fang P, Madoux F, Spicer T, Scampavia L, Kim S, Guo M 101 – Collia D, Bannister T, Tan H, Jin S, Langaee T, Shumate J, Scampavia L, Spicer T 100 – Janovick JA, Spicer TP, Scampavia L, Conn PM 99 – Powell K 97 – Madoux F, Tanner A, Vessels M, Willetts L, Hou S, Scampavia L, Spicer T. 96 – Madoux F, Dreymuller D, Pettiloud JP, Santos R, Becker-Pauly C, Ludwig A, Fields GB, Bannister T, Spicer TP, Cudic M, Scampavia LD, Minond D 95 – Wang J, Fang P, Chase P, Tshori S, Razin E, Spicer TP, Scampavia L, Hodder P, Guo M 94 – Swingle M, Volmar CH, Saldanha SA, Chase P, Eberhart C, Salter EA, D’Arcy B, Schroeder CE, Golden JE, Wierzbicki A, Hodder P, Honkanen RE 93 – Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Weisman RL, Kelly JW. 92 – Janovick JA, Spicer TP,Smith E, Bannister TD, Kenakin T, Scampavia L, Conn PM. 91 – Smith E, Janovick JA, Bannister TD, Shumate J, Scampavia L, Conn PM, Spicer TP. 90 – Ewing H, Fernandez-Vega V, Spicer T, Chase P, Brown S, Scampavia L, Roush W, Riley S, Rosen H, Hodder P, Lambeau G, Gelb M. 89 – Thenin-Houssier S, de Vera IM, Pedro-Rosa L, Brady A, Richard A, Konnick B, Opp S, Buffone C, Fuhrmann J, Kota S, Billack B, Pietka-Ottlik M, Tellinghuisen T, Choe H, Spicer T, Scampavia L, Diaz-Griffero F, Kojetin DJ, Valente ST. 88 – Jambrina E, Cerne R, Smith E, Scampavia L, Cuadrado M, Findlay J, Krambis M, Wakulchik M, Chase P, Brunavs M, Burris K, Gallagher P, Spicer T, Ursu D. 87 – Chase P, Enogieru I, Madoux F, Bishop E, Beer J, Scampavia L, Spicer T. 86 – Palde PB, Bhaskar A, Pedró Rosa LE, Madoux F, Chase P, Gupta V, Spicer T, Scampavia L, Singh A, Carroll KS. . 85 – Sanders MA, Madoux F, Mladenovic L, Zhang H, Ye X, Angrish M, Mottillo EP, Caruso JA, Halvorsen G, Roush WR, Chase P, Hodder P, Granneman JG. 84 – Abdul-Hay SO, Bannister TD, Wang H, Cameron MD, Caulfield TR, Masson A, Bertrand J, Howard EA, McGuire MP, Crisafulli U, Rosenberry TR, Topper CL, Thompson CR, Schurer SC, Madoux F, Hodder P, Leissring MA. 83 – Conn PM, Spicer TP, Scampavia L, Janovick JA. 82 – Schreiber S, Kotz J, Li M, Aube J, Austin C, Reed J, Rosen H, White E, Sklar L, Lindsley C, Alexander B, Bittker J, Clemons P, Souza A, Foley M, Palmer M, Shamji A, Wawer M, McManus O, Wu M, Zou B, Yu H, Golden J, Schoenen F, Simenov A, Jadhav A, JAckson M, Pinkerton A, Chung T, Griffin P, Cravatt B, Hodder P, Roush W, Roberts E, Chung D, Jonsson C, Noah J, Severson W, Ananthan S, Edwards B, Oprea T, Conn PM, Hopkins C, Wood M, Stauffer S, Emmitte K 81 – Smith E, Chase P, Niswender C, Utley T, Sheffler D, Noetzel M, Lamsal A, Wood M, Conn PJ, Lindsley C, Madoux F, Acosta M, Scampavia L, Spicer T, Hodder P. 80 – Chang J, Zuhl A, Speers A, Niessen S, Brown S, Mulvihill M, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Ferguson J, Dix M, Hodder P, Rosen H, Nomura D, Kwon O, Hsu K-L, Cravatt B. 79 – Madoux F, Janovick JA, Smithson D, Fargue S, Danpure CJ, Scampavia L, Chen YT, Spicer TP, Conn PM. 78 – Wang Y, Stowe RL, Pinello CE, Tian G, Madoux F, Li D, Zhao LY, Li JL, Wang Y, Wang Y, Ma H, Hodder P, Roush WR, Liao D 77 – Cameron M, Kamenecka T, Madoux F, Chase P, Roush W, Hodder P 76 – Zhao N1, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, Rosen H, Spicer TP, Nathan CF 75 – Kadakkuzha BM, Spicer TP, Chase P, Richman JB, Hodder P, Puthanveettil SV. 74 – Timothy P. Spicer, Jianwen Jiang, Alexander B. Taylor, Jun-Yong Choi, P. JohnHart, William R. Roush, Gregg B. Fields, Peter S. Hodder, and Dmitriy Minond 73 – Pedró-Rosa L, Buckner FS, Ranade RM, Eberhart C, Madoux F, Gillespie JR, Koh CY, Brown S, Lohse J, Verlinde CL, Fan E, Bannister T, Scampavia L, Hol WG, Spicer T, Hodder P 72 – Gentry PR, Kokubo M, Bridges TM, Noetzel MJ, Cho HP, Lamsal A, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Wood MR 71 – Madoux F, Tredup C, Spicer TP, Scampavia L, Chase PS, Hodder PS, Fields GB, Becker-Pauly C, Minond D 70 – Conn PM, Smith E, Spicer T, Chase P, Scampavia L, Janovick JA 69 – Sturchler E, Chen W, Spicer T, Hodder P, McDonald P, Duckett D 68 – Penas C, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ, Chauhan R, Barnaby O, Schurer S, Hodder P, Steen J, Roush WR, Ayad NG 67 – Yan F, Yu Y, Chow DC, Palzkill T, Madoux F, Hodder P, Chase P, Griffin PR, O’Malley BW, Lonard DM 66 – Gentry PR, Kokubo M, Bridges TM, Cho HP, Smith E, Chase P, Hodder PS, Utley TJ, Rajapakse A, Byers F, Niswender CM, Morrison RD, Daniels JS, Wood MR, Conn PJ, Lindsley CW 65 – Spicer T, Fernandez-Vega V, Chase P, Scampavia L, To J, Dalton JP, Da Silva FL, Skinner-Adams TS, Gardiner DL, Trenholme KR, Brown CL, Ghosh P, Porubsky P, Wang JL, Whipple DA, Schoenen FJ, Hodder P 64 – Lewallen DM, Bicker KL, Madoux F, Chase P, Anguish L, Coonrod S, Hodder P, Thompson PR 63 – Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O’Malley BW 62 – Conn PM, Smithson DC, Hodder PS, Stewart MD, Behringer RR, Smith E, Ulloa-Aguirre A, Janovick JA 61 – Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR 60 – Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl EL, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aube J, Bohn LM 59 – Gentry PR, Kokubo M, Bridges TM, Kett NR, Harp JM, Cho HP, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Wood MR, Lindsley CW 58 – Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer TP, Chase PS, Hodder PS, Schaeffer MT, Brown S, Rosen H, Roberts E 57 – Turlington M, Chun A, Tomar S, Eggler A, Grum-Tokars V, Jacobs J, Daniels JS, Dawson E, Saldanha A, Chase P, Baez-Santos YM, Lindsley CW, Hodder P, Mesecar AD, Stauffer SR 56 – Richard DJ, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH 55 – Satsu H, Schaeffer MT, Guerrero M, Saldana A, Eberhart C, Hodder P, Cayanan C, Schürer S, Bhhatarai B, Roberts E, Rosen H, Brown SJ 54 – Gomes I, Fujita W, Gupta A, Saldanha SA, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA 53 – Conn PM, Smith E, Hodder P, Janovick JA, Smithson DC 52 – Yang H, Pinello CE, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Chase P, Planck J, Geary KR, Ma H, Law BK, Roush WR, Hodder P, Liao D 51 – Thomas PW, Spicer T, Cammarata M, Brodbelt JS, Hodder P, Fast W 50 – Karapetyan YE, Sferrazza GF, Zhou M, Ottenberg G, Spicer T, Chase P, Fallahi M, Hodder P, Weissmann C, Lasmézas CI 49 – Gentry PR, Bridges TM, Lamasal A, Vinson PN, Smith E, Chase P, Hodder PS, Engers JL, Niswender CM, Scott Daniels J, Jeffrey Conn P, Wood MR, Lindsley CW 48 – Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF 47 – Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, Eggler A, Dawson ES, Baez-Santos YM, Tomar S, Mielech AM, Baker SC, Lindsley CW, Hodder P, Mesecar A, Stauffer SR 46 – Qin Q, Knapinska A, Dobri N, Madoux F, Chase P, Hodder P, Petrukhin K 45 – Urbano M, Guerrero M, Zhao J, Velaparthi S, Adrian Saldanha S, Chase P, Wang Z, Civelli O, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E 44 – Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF 43 – Amundsen SK, Spicer T, Karabulut AC, Londoño LM, Eberhart C, Fernandez Vega V, Bannister TD, Hodder P, Smith GR 42 – Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, Morimoto RI 41 – Guerrero M, Urbano M, Zhao J, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E 40 – Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR 39 – Urbano M, Guerrero M, Velaparthi S, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E 38 – Peatey CL, Spicer T, Hodder P, Trenholme KR, Gardiner DL 37 – Tsuboi K, Bachovchin DA, Speers AE, Spicer TP, Fernandez-Vega V, Hodder P, Rosen H, Cravatt BF 36 – Bialkowska A, Crisp M, Bannister T, He Y, Chowdhury S, Schurer S, Chase P, Spicer T, Madoux F, Tian C, Hodder P, Zaharevitz D, Yang VW 35 – Lone AM, Bachovchin D, Westwood D, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder P, Rosen H, Cravatt BF, Saghatelian A 34 – Baillargeon P, Scampavia L, Einsteder R, Hodder P 33 – Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF 32 – Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ 31 – Istrate MA, Spicer TP, Wang Y, Bernard JA, Helvering LM, Bocchinfuso WP, Richardson TI, Zink R, Kumar N, Montrose-Rafizadeh C, Dodge J, Hodder P, Griffin PR 30 – Doghman M, Madoux F, Hodder P, Lalli E 29 – Madoux F, Simanski S, Chase P, Mishra JK, Roush WR, Ayad NG, Hodder PS 28 – Weide T, Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder P, Fokin VV 27 – Brunell D, Weissbach H, Hodder P, Brot N 26 – Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF 25 – Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S 24 – Tanaka K, Koresawa M, Iida M, Fukasawa K, Stec EM, Cassaday J, Chase P, Rickert K, Hodder P, Takagi T, Komatani H 23 – Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD 22 – Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS 21 – Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P 20 – Doghman M, Cazareth J, Douguet D, Madoux F, Hodder P, Lalli E 19 – Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer MT, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H 18 – Chung CC, Ohwaki K, Schneeweis JE, Stec E, Varnerin JP, Goudreau PN, Chang A, Cassaday J, Yang L, Yamakawa T, Kornienko O, Hodder P, Inglese J, Ferrer M, Strulovici B, Kusunoki J, Tota MR, Takagi T 17 – Roth J, Madoux F, Hodder P, Roush WR 16 – Lauer-Fields JL, Minond D, Chase PS, Baillargeon PE, Saldanha SA, Stawikowska R, Hodder P, Fields GB 15 – Madoux F, Li X, Chase P, Zastrow G, Cameron MD, Conkright JJ, Griffin PR, Thacher S, Hodder P 14 – Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P 13 – Lauer-Fields JL, Spicer TP, Chase PS, Cudic M, Burstein GD, Nagase H, Hodder P, Fields GB 12 – Marine S, Stec E, Chase P, Hoffman I, Szymanski S, Simon A, Shi X, Bartz S, Bagchi A, Minch E, Majercak J, Koblan K, Hazuda D, Shearman M, Gates A, Xu M, Rosahl T, Beher D, Ray W, Stone D, Espeseth A, Ferrer M, Strulovici B 11 – Hodder PS 10 – Hodder PS 9 – Zuck P, O’Donnell GT, Cassaday J, Chase P, Hodder P, Strulovici B, Ferrer M 8 – Hale JJ, Lynch CL, Neway W, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Parent SA, Chrebet G, Bergstrom J, Card D, Ferrer M, Hodder P, Strulovici B, Rosen H, Mandala S 7 – Hodder P, Mull R, Cassaday J, Berry K, Strulovici B 6 – Kunapuli P, Ransom R, Murphy KL, Pettibone D, Kerby J, Grimwood S, Zuck P, Hodder P, Lacson R, Hoffman I, Inglese J, Strulovici B 5 – Hodder P, Cassaday J, Peltier R, Berry K, Inglese J, Feuston B, Culberson C, Bleicher L, Cosford ND, Bayly C, Suto C, Varney M, Strulovici B 4 – Hodder PS, Beeson C, Ruzicka J 3 – Scampavia LD, Hodder PS, Lähdesmäki I, Ruzicka J 2 – Hodder PS, Ruzicka J 1 – Hodder PS, Blankenstein G, Ruzicka J
Protocol for Kinetic Mode Potassium Channel Assays on Common Plate Readers and Microscopes
SLAS Discovery. 2024 March.
Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins
Journal of Medicinal Chemistry. 2024 January. 38252624
Protocol for High Throughput 3D Drug Screening of Patient Derived Melanoma and Renal Cell Carcinoma
SLAS Discovery. 2024 January. 38218316
Neutral ceramidase-active site inhibitor chemotypes and binding modes
Bioorganic Chemistry. 2023 October. 37531819
A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer
Cell Death & Disease. 2023 September. 37398312
In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma
Cancers. 2023 June. 37444398
Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism
Nature – Signal Transduction and Targeted Therapy. 2023 February. 36849489
High throughput assay for compounds that boost BDNF expression in neurons
SLAS Discovery. 2023 February. 36842668
Protocol for 3D Screening of Lung Cancer Spheroids using Natural Products
SLAS Discovery. 2023 January. 36681384
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Nature – Cell Research. 2023 January. 36588115
High Throughput Screening for Drugs that Inhibit 3C-Like Protease in SARS-CoV-2
SLAS Discovery. 2023 January. 36646172
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis.
ACS Chem Biol. 2022 June. 35658397
Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 Mpro/3CLpro in Living Cells.
mBio 2022 April. 35471084
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models
SLAS Discovery. 2022 Mar. 35339725
High throughput screening for compounds to the orphan nuclear receptor NR2F6
SLAS Discovery. 2022 Mar. 35331960
Lead Identification using 3D Models of Pancreatic Cancer
SLAS Discovery. 2022 Mar. 35306207
Screening for Modulators of Autism Spectrum Disorder Using Induced Human Neurons
SLAS Discovery. 2022 Feb. 35123134
Rapid Deployment of Inexpensive Open-Source Orbital Shakers in Support of High-Throughput Screening
SLAS Technology. 2022 Jan. 35066236
Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel
PLoS Negl Top Dis. 2021 Nov. 34731172
Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 Entry
SLAS Discovery<. 2021 October. 35058179
Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay
Bioorganic & Medicinal Chemistry. 2021 July. 34130216
Identification of Potential Modulators of the RGS7/G�5/R7BP Complex
SLAS Discovery. 2021 June. 34112017
Development and Pilot Screen of Novel High Content Assay for Down Regulators of Expression of Heterogenous Nuclear Ribonuclear Protein H2
Cell Physiology & Biochemistry. 2021 May. 34014051
Discovery and Optimization of Selective Inhibitors of Meprin a (Part II)
Pharmaceuticals. 2021 February. 33673639
Discovery and Optimization of Selective Inhibitors of Meprin a (Part I)
Pharmaceuticals. 2021 January. 33671080
Drug Discovery Targeting COVID-19
SLAS Discovery. 2020 December. 33215959
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2
SLAS Discovery. 2020 October. 33043784
Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR
SLAS Discovery. 2020 October. 33016182
SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons
Journal of Neuroscience. 2020 September. 32887745
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
Nature Chemical Biology. 2020 July. 32690944
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening
SLAS Discovery. 2020 July. 32734807
Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity
Nature Scientific Reports. 2020 June. 32601341
Prioritizing targeted therapies in an evidence-based manner, integrating biological context and functional precision medicine
Journal of Clinical Oncology. 2020 May.
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment
Science Advances. 2020 April. 32494682
An Unbiased High-Throughput Drug Screen Reveals a Potential Therapeutic Vulnerability in the Most Lethal Molecular Subtype of Pancreatic Cancer
Molecular Oncology. 2020 June. 32533886
Abstract C39: A novel rewired pathway of nucleotide metabolism drives chemoresistance in pancreatic cancer
AACR Special Conference on Pancreatic CAncer: Advances in Science and Clinical Care. 2019 December.
Drug Discovery and Development, Third Edition
CRC Press. 2019 December.
Applications for Open Source Microplate-Compatible Illumination Panels
JoVE. 2019 October. PMID:31633701
121 – Baillargeon P, Shumate J, Hou S, Fernandez-Vega V, Marques N, Souza G, Seldin J, Spicer TP, Scampavia L
Automating a Magnetic 3D Spheroid Model Technology for High-Throughput Screening
SLAS Technology. 2019 June. PMID:31225974
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons
Nature Scientific Reports. 2019 June. PMID:31227747
Stabilization of amyloidogenic immunoglobulin light chains by small molecules
PNAS. 2019 April. PMID:30971495
Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins
ACS Infect Dis. 2019 Feb. PMID:30485744
Design of Microplate-Compatible Illumination Panels for a Semiautomated Benchtop Pipetting System
SLAS Technology. 2019 January. PMID:30698997
The Scripps Molecular Screening Center and Translational Research Institute
SLAS Discovery. 2019 January. PMID:30682260
A Novel 3D Culture System for High-Throughput Hepatoxicity Screening
BioProcess International. 2018 October. PMID:
Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay
SLAS Discovery. 2018 August. PMID:30142014
Chemical Validation and Optimization of Pharmacoperones Targeting Vasopressin Type 2 Receptor Mutant
Biochem J. 2018 August. PMID:30068530
Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119
Assay Drug Dev Technol. 2018 July. PMID:30019946
A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells
SLAS Discovery. 2018 May. PMID:29750582
A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype
Oncogene. 2018 May. PMID:29743592
A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/GB5/R7BP Complex
Assay Drug Dev Technol. 2018 Apr. PMID:29658790
Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening
SLAS Discovery. 2018 Apr. PMID:29673279
IoT for Real-Time Measurement of High-Throughput Liquid Dispensing in Laboratory Environments
SLAS Technology. 2018 Apr. PMID:29649373
Dynamic changes during the treatment of pancreatic cancer.
Oncotarget. 2018 Feb. PMID:29599906
A Homogeneous Cell-Based Halide-Sensitive Yellow Fluorescence Protein Assay to Identify Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Ion Channel.
Assay Drug Dev Technol. 2017 Nov. PMID:29172645
Improved Scalability of Neuron-Based Phenotypic Screening Assays for Therapeutic Discovery in Neuropsychiatric Disorders.
Molecular Neuropsychiatry. 2017 Nov. PMID:29594133
Using bead injection to model dispensing of 3-D multicellular spheroids into microtiter plates.
Talanta. 2017 Sep. PMID:29108585
High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases.
SLAS Discovery. 2017 Oct. PMID:29020503
A Rapid Phenotypic Whole-Cell Screening Approach for the Identification of Small-Molecule Inhibitors That Counter B-Lactamase Resistance in Pseudomonas aeruginosa.
SLAS Discovery. 2017 Aug. PMID:28850797
Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.
PLoS One. 2017 Aug. PMID:28767678
Adding depth to cell culture.
Science. 2017 Apr. PMID:
98 – Hou S, Madoux F, Scampavia L, Janovick JA, Conn PM, Spicer TP
Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease.
SLAS Discovery. 2017 Jan. PMID:28346094
A 1536-Well 3D Viability Assay to Assess the Cytotoxic Effect of Drugs on Spheroids.
SLAS Discovery. 2017 Jan. PMID:28346088
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate.
Sci Rep. 2016 Dec. PMID:27920432
Development of an HTS-Compatible Assay for Discovery of Melanoma-Related Microphthalmia Transcription Factor Disruptors Using AlphaScreen Technology.
Journal of Biomolecular Screening. 2016 Nov. PMID:27827304
An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C).
J Biomol Screen. 2016 Sept. PMID:27628691
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
Elife. 2016 Jul 20. PMID:27435961
Receptor antagonism/agonism can be uncoupled from pharmacoperone activity.
Mol Cell Endocrinol. 2016 Jul 4. PMID:27389877
Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.
Journal of Biomolecular Screening. 2016 Jun 8. PMID:27280550
Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles.
Journal of Biomolecular Screening. 2016 May 4. PMID:27146384
Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication
Antimicrobial Agents and Chemotherapy. 2016 Mar. 25 PMID:26810656
An Integrated Approach for Screening and Identification of Positive Allosteric Modulators of N-Methyl-D-Aspartate Receptors.
Journal of Biomolecular Screening. 2016 Feb 2. PMID:26838761
An Automated Miniaturized Method to Perform and Analyze Antimicrobial Drug Synergy Assays.
Assay and Drug Development Technologies. 2015 Dec 15. PMID:26669516
First-In-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis.
ACS Chem Biol. 2015 Nov 2. PMID:26524379
Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.
Cell Metab. 2015 Sep 22. PMID:26411340
Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors.
ACS Chem Biol. 2015 Sep 23. PMID:26398879
Assay strategies for identification of therapeutic leads that target protein trafficking.
Trends Pharmacol Sci. 2015 Jun 8. PMID:26067100
Advancing Biological Understanding and Therapeutics Discovery with Small Moleucle Probes.
Cell. 2015 Jun 4. PMID:26046436
Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4).
J Biomol Screen. 2015 Apr 16. PMID:25877150
A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.
ACS Chem Biol. 2015 Jan 20. PMID:25602368
Development of a Phenotypic High-Content Assay to Identify Pharmacoperone Drugs for the Treatment of Primary Hyperoxaluria Type 1 by High-Throughput Screening
Assay Drug Dev Technol. 2015 January/February;13(1):16-24. PMID:25710543
Identification of Histone Deacetylase Inhibitors with Benzoylhydrazide Scaffold that Selectively Inhibit Class I Histone Deacetylases
Chem Biol. 2015 Feb 19;22(2):273-84. doi: 10.1016/j.chembiol.2014.12.015. PMID:25699604
ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450 Enzyme CYP3A4
Probe Reports from the NIH Molecular Libraries Program. PMID:21433368
Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis
ACS Chem Biol. 2014 Dec 5. [Epub ahead of print]. PMID:25457457
High-throughput screening for small molecule modulators of motor protein Kinesin.
Assay Drug Dev Technol. 2014 Oct. PMID:25383721
Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation In Vitro
J Medicinal Chemistry. 2014 Oct 20. [Epub ahead of print]. PMID:25330343
Identification of Potent Inhibitors of the Trypanosoma brucei Methionyl-tRNA Synthetase via High-Throughput Orthogonal Screening
J Biomol Screen. 2014 Aug 27. pii: 1087057114548832. [Epub ahead of print]. PMID: 25163684
Development of a Highly Potent, Novel M5 Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)
J Med Chem. 2014 Aug 22. [Epub ahead of print]. PMID: 25147929
Development of HTS assays and pilot screen for inhibitors of metalloproteases meprin α and β
Biopolymers. 2014 Jul 21. doi: 10.1002/bip.22527. [Epub ahead of print]. PMID: 25048711
A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor
Assay Drug Dev Technol. 2014 May;12(4):238-46. doi: 10.1089/adt.2014.576. PMID: 24831790
Development of an HTS-Compatible Assay for the Discovery of ASK1 Signalosome Inhibitors Using AlphaScreen Technology
Assay Drug Dev Technol. 2014 May;12(4):229-37. doi: 10.1089/adt.2013.558. PMID: 24831789
Casein Kinase 1δ Dependent Wee1 Degradation
J Biol Chem. 2014 Jul 4;289(27):18893-18903. Epub 2014 May 9. PMID: 24817118
Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor
PLoS One. 2014 Apr 17;9(4):e95243. doi: 10.1371/journal.pone.0095243. eCollection 2014. PMID: 24743578
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5 -Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe
ChemMedChem. 2014 Aug;9(8):1677-82. doi: 10.1002/cmdc.201402051. Epub 2014 Apr 1. PMID: 24692176
Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening
J Biomol Screen. 2014 Mar 11. [Epub ahead of print]. PMID: 24619116
A FluoPol-ABPP PAD2 High-Throughput Screen Identifies the First Calcium Site Inhibitor Targeting the PADs
ACS Chem Biol. 2014 Apr 18;9(4):913-21. doi: 10.1021/cb400841k. Epub 2014 Jan 27. PMID: 24467619
Bufalin is a potent small molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1
Cancer Res. 2014 Mar 1;74(5):1506-17. doi: 10.1158/0008-5472.CAN-13-2939. Epub 2014 Jan 3. PMID: 24390736
Transitioning pharmacoperones to therapeutic use: In vivo proof-of-principle and design of high throughput screens
Pharmacol Res. 2014 May;83:38-51. doi: 10.1016/j.phrs.2013.12.004. Epub 2013 Dec 25. PMID: 24373832
Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation
ACS Chem Biol. 2014 Feb 21;9(2):433-42. doi: 10.1021/cb4006886. Epub 2013 Nov 25. PMID: 24274060
Development of functionally selective, small molecule agonists at kappa opioid receptors
J Biol Chem. 2013 Dec 20;288(51):36703-16. doi: 10.1074/jbc.M113.504381. Epub 2013 Nov 1. PMID: 24187130
Discovery of the First M5-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
J Med Chem. 2013 Nov 27;56(22):9351-5. doi: 10.1021/jm4013246. Epub 2013 Nov 13. PMID: 24164599
Discovery, design and synthesis of a selective S1P3 receptor allosteric agonist
Bioorg Med Chem Lett. 2013 Dec 1;23(23):6346-9. doi: 10.1016/j.bmcl.2013.09.075. Epub 2013 Oct 1. PMID: 24135724
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
Bioorg Med Chem Lett. 2013 Nov 15;23(22):6172-7. doi: 10.1016/j.bmcl.2013.08.112. Epub 2013 Sep 7. PMID: 24080461
Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker
Bioorg Med Chem. 2013 Nov 1;21(21):6642-6649. doi: 10.1016/j.bmc.2013.08.017. Epub 2013 Aug 15. PMID: 23993674
A sphingosine 1-phosphate receptor 2 selective allosteric agonist
Bioorg Med Chem. 2013 Sep 1;21(17):5373-82. doi: 10.1016/j.bmc.2013.06.012. Epub 2013 Jun 15. PMID: 23849205
Identification of a mu-delta opioid receptor heteromer-biased agonist with antinociceptive activity
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12072-7. doi: 10.1073/pnas.1222044110. Epub 2013 Jul 1. PMID: 23818586
High-throughput screen for pharmacoperones of the vasopressin type 2 receptor
J Biomol Screen. 2013 Sep;18(8):930-7. doi: 10.1177/1087057113483559. Epub 2013 May 2. PMID: 23640875
Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents
Mol Cancer Ther. 2013 May;12(5):610-20. doi: 10.1158/1535-7163.MCT-12-0930. Epub 2013 Apr 26. PMID: 23625935
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening
>Bioorg Med Chem. 2013 Jun 1;21(11):3138-46. doi: 10.1016/j.bmc.2013.03.031. Epub 2013 Mar 29. PMID: 23591260
Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7044-9. doi 10.1073/pnas.1303510110. Epub 2013 Apr 1. PMID: 23576755
Discovery of ML326: The first sub-micromolar, selective M5 PAM
Bioorg Med Chem Lett. 2013 May 15;23(10):2996-3000. doi: 10.1016/j.bmcl.2013.03.032. Epub 2013 Mar 16. PMID: 23562060
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)
Bioorg Med Chem Lett. 2013 Feb 1;23(3):839-43. doi: 10.1016/j.bmcl.2012.11.061. Epub 2012 Dec 2. PMID: 23260346
Discovery, synthesis, and structure-based optimization of a series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease
J Med Chem. 2013 Jan 24;56(2):534-46. doi: 10.1021/jm301580n. Epub 2013 Jan 3. PMID: 23231439
In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3
J Ocul Pharmacol Ther. 2013 Apr;29(3):298-309. doi: 10.1089/jop.2012.0.0135. Epub 2012 Oct 25. PMID: 23098562
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
Bioorg Med Chem Lett. 2012 Dec 1;22(23):7135-41. doi: 10.1016/j.bmcl.2012.09.074. Epub 2012 Oct 2. PMID: 23079522
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes
J Am Chem Soc. 2012 Jun 27;134(25):10345-8. Epub 2012 Jun 12. PMID: 22690931
Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes
ACS Chem Biol. 2012 May 18;7(5):879-91. Epub 2012 Mar 23. PMID: 22443934
Small-molecule proteostasis regulators for protein conformational diseases
Nat Chem Biol. 2011 Dec 25;8(2):185-96. doi: 10.1038/nchembio.763. PMID: 22198733
Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists
Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42. Epub 2011 Nov 4. PMID: 22119461
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds
Bioorg Med Chem Lett. 2011 Dec 1;21(23):7180-4. Epub 2011 Sep 22. PMID: 22018790
Discovery, synthesis and SAR analysis of novel selective small molecule S1P(4)-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype
Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45. Epub 2011 Sep 20. PMID: 21982495
A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes
Mol Biochem Parasitol. 2011 Dec;180(2):127-31. Epub 2011 Sep 16. PMID: 21939693
Potent and selective inhibitors of Glutathione S-transferase Omega 1 that impair cancer drug resistance
J Am Chem Soc. 2011 Oct 19;133(41):16605-16. Epub 2011 Sep 27. PMID: 21899313
Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening
Mol Cancer Ther. 2011 Nov;10(11):2043-51. Epub 2011 Sep 1. PMID: 21885866
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors
J Am Chem Soc. 2011 Aug 3;133(30):11665-74. Epub 2011 Jun 21. PMID: 21692504
Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument
J Lab Autom. 2011 Jun;16(3):197-203. Epub 2011 May 16. PMID: 21609702
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6. Epub 2011 Mar 11. PMID: 21398589
Reversible inhibitor of p97 DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. Epub 2011 Mar 7. PMID: 21383145
Development of an HTS-compatible assay for discovery of ROR? modulators using AlphaScreen® technology
J Biomol Screen. 2011 Feb;16(2):183-91. PMID: 21297105
Identification and characterization of steroidogenic factor-1 inverse agonists
Methods Enzymol. 2010;485:3-23. PMID: 21050908
An ultra-high throughput cell-based screen for Wee1 degradation inhibitors
J Biomol Screen. 2010 Sep;15(8):907-17. Epub 2010 Jul 26. PMID: 20660794
NH-1,2,3-triazole-based inhibitors of the VIM-2 metallo-beta-lactamase: synthesis and structure-activity studies.
ACS Med Chem Lett. 2010 Jul 8;1(4):150-154. PMID: 20625539
A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A
Assay Drug Dev Technol. 2010 Oct;8(5):615-20. Epub 2010 Jun 1. PMID: 20515413
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9)
Bioorg Med Chem Lett. 2010 Apr 1;20(7):2254-8. Epub 2010 Feb 6. PMID: 20207142
Small molecule activators of TRPML3
Chem Biol. 2010 Feb 26;17(2):135-48. PMID: 20189104
Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screen
Assay Drug Dev Technol. 2010 Feb;8(1):47-62. PMID: 20085455
A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization
Assay Drug Dev Technol. 2010 Feb;8(1):96-105. PMID: 20035614
Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening
Mol Pharmacol. 2010 Jan;77(1):46-57. Epub 2009 Oct 16. PMID: 19837904
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries
Bioorg Med Chem. 2009 Jul 15;17(14):5027-37. Epub 2009 Jun 22. PMID: 19553129
Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists
J Clin Endocrinol Metab. 2009 Jun;94(6):2178-83. Epub 2009 Mar 24. PMID: 19318454
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening
ACS Chem Biol. 2008 Aug 15;3(8):486-98. Epub 2008 Jul 1. PMID: 18590333
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production
Assay Drug Dev Technol. 2008 Jun;6(3):361-74. PMID: 18452391
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds
Bioorg Med Chem Lett. 2008 Apr 15;18(8):2628-32. Epub 2008 Mar 14. PMID: 18374567
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate
Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. Epub 2008 Mar 6. PMID: 18358729
Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening
Mol Pharmacol. 2008 Jun;73(6):1776-84. Epub 2008 Mar 11. PMID: 18334597
Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of rho-kinase II (ROCK-II)
J Biomol Screen. 2008 Jan;13(1):17-28. PMID: 18227223
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate
Anal Biochem. 2008 Feb 1;373(1):43-51. Epub 2007 Sep 15. PMID: 17949675
Activity profile-based siRNA screen to explore the functional genomics of Alzheimer’s disease
BioTechniques. 2007 Dec;43(6):Sxxii-Sxxvii. ARTICLE.
Building a uHTS laboratory
Drug Discovery World. 2005 Winter;6:31-42. ARTICLE.
Integration of miniaturisation technologies into the high throughput screening laboratory
European Pharmaceutical Review. 2005 May 20;2:47-55
Miniaturization of absorbance assays using the fluorescent properties of white microplates
Anal Biochem. 2005 Jul 15;342(2):254-9. PMID: 15949786
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists
J Med Chem. 2004 Dec 30;47(27):6662-5. PMID: 15615513
Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader
J Biomol Screen. 2004 Aug;9(5):417-26. PMID: 15296641
Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening
Anal Biochem. 2003 Mar 1;314(1):16-29. PMID: 12633598
Identification of metabotropic glutamate receptor antagonists using an automated high throughput screening system
Anal Biochem. 2003 Feb 15;313(2):246-54. PMID: 12605861
Equilibrium and kinetic measurement of muscarinic receptor antagonism on living cells using bead injection spectroscopy
Anal Chem. 2000 Jul 15;72(14):3109-15. PMID: 10939374
Automation of functional assays by flow injection fluorescence microscopy
Trends Biotechnol. 1999 Nov;17(11):443-7. PMID: 10511702
A flow injection renewable surface technique for cell-based drug discovery functional assays
Anal Chem. 1999 Mar 15;71(6):1160-6. PMID: 10093496
Microfabricated flow chamber for fluorescence-based chemistries and stopped-flow injection cytometry
Analyst. 1997 Sep;122(9):883-7. PMID: 9374023